Articol Articol

Synthesis of a New Series of thiazolylmethyl(carbonyl-methyl)-oxibenz aldehyde Derivatives

A new series of thiazolyl-methyl (carbonyl-methyl)-oxi-benzaldehydes (5, 8-12) was prepared by the reaction between a series of 2-aryl-thiazoles and o, m or p-OH benzaldehyde. The obtained aldehydes were used as key intermediates for the synthesis of 2-thioxo-1,3-thiazolidin-4-one derivatives (13-16) and of pyrimidine-2,4,6-trione derivatives (17-19). The structures of the newly synthesized compounds were confirmed by TLC, elemental analysis and spectroscopic (MS, IR, 1H NMR) data.

Synthesis of a New Series of thiazolylmethyl(carbonyl-methyl)-oxibenz aldehyde Derivatives.   |   ro  

Farmacia

Volum 057 | Număr 04 | Publicat la 01/01/2009 | Pagini:  452

Autori:
Cristina Moldovan [1]
[1] “Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj Napoca, Romania
Rezumat

Au fost obţinute noi serii de tiazolil-metil(carbonil-metil)-oxi-benzaldehide (5, 8-12) prin reacţia dintre o serie de 2-aril-tiazoli şi o, m sau p-OH benzaldehidă. Aldehidele obţinute au fost utilizate ca intermediari cheie în sinteza unor derivaţi de 2-tioxo-1,3-tiazolidin-4-onă (13-16) şi de pirimidin-2,4,6-trionă (17-19). Structurile noilor compuşi sintetizaţi au fost confirmate prin CSS, analiză elementală şi spectroscopie (SM, IR, 1H RMN).

Cuvinte cheie:
2-Aryl-thiazoles, 2-thioxo-1,3-thiazolidin-4-one derivatives, pyrimidine-2,4,6-trione derivatives
©   UEFISCDI 2010
Sus



Evaluarea articolului:

Cosul de Cumparaturi Cosul de Cumparaturi