An overview on nervous conduits and stem cells association Nowadays it is unanimously accepted in the specialty scientific medical world that an axon physical guidance is vital for the repair of injured peripheral nerves. Nerve guidance channels represent a diffusion pathway for growth factors secreted by the injured nerves and they also decrease the development of scar tissue. The researches in this domain were axed on the use of natural and synthetic materials for nervous conduits (NC) manufacture. Lately, the studies have been centered on the combination of more materials and bio-molecules in order to develop new composite materials that can stimulate nervous regeneration. Also demonstrated was the importance of neurotrophic factors (neurotrophins, neuronal growth factor, fibroblastic growth factor, etc) and cell adhesion molecules presence. To enhance the performances of the biomaterials used for the manufacture of NC, the effect of Schwann and other cell introduction in these structures was also tested. The biocompatible biomaterial domain is very dynamic, the researches leading to the achievement of new more efficient types. These will improve the prognosis of nerve sections with loss of motor, sensory, or both functions. Peripheral nerve regeneration by mean of efficient NC became a priority for plastic surgeons, neurologists and neurosurgeons. NC achievement in a shape that will ensure patients’ rapid and precise healing is a challenge for the biomaterial research domain.

An overview on nervous conduits and stem cells association. -